World Journal of
Pharmaceutical and Life Sciences

ADVANCEMENTS IN OPHTHALMIC IN SITU GEL DRUG DELIVERY SYSTEMS: DEVELOPMENT, EVALUATION, AND CHARACTERISTICS

Avadhut Khot* and Gauri Kadam

ABSTRACT

Eyes are delicate and vulnerable to trauma and infections. The placement of medications or adding Drug delivery
into the eye is extremely challenging because of the precorneal zone's removal mechanisms which decreases the
precision. The cornea’s rapid absorption and depletion, along with diminishing pharmacological effects, are some
of the shortcomings associated with the conventional ocular delivery system, which uses sperms, lotions, and
emulsions, which are somewhat effective. Conversely, in situ polymeric systems are able to maintain the desired
concentration of the drug at the site of action such that maximum therapeutic action can be achieved. New
formulated ocular drug delivery systems include in-situ gels, dendrimers, niosomes, and Ocusert as well as others.
In situ gelling systems begins as a liquid before application but transforms into a gel following application, when
there’s a change in temperature, pH, or ions. Many efforts for the formulation of long acting in-situ gels have been
undertaken. Recent works in ocular drug delivery have been directed towards the use of a variety of drug delivery
technologies to design a system that enhances the residence time of the drug at the eye surface while at the same
time diminishes the rate of clearance. The review highlights the features, strategies and assessment of
methodologies.

[Full Text Article]   [Download Certificate]