World Journal of
Pharmaceutical and Life Sciences

A COMPARATIVE CLINICAL STUDY ON SERO-POSITIVE AND SERO-NEGATIVE RHEUMATOID ARTHRITIS W.S.R. TO AMAVATA AND ITS MANAGEMENT WITH VATARI GUGGULU AND GUDUCHI SATWA

Dr. Simadri Bhusan Nayak* and Prof (Dr.) Pradeep Kumar Panda

ABSTRACT

Amavata is a disease mentioned in ancient text like Charak Samhita, but detail description of its causes, signs, symptoms are given in Madhav nidana, which can be directly co-relate to an auto immune disorder” Rheumatoid arthritis”, whose signs & symptoms according to American society of rheumatoid arthritis are quite same with Amavata. This rheumatoid arthritis is of two types, one is sero-positive and another sero-negative. As it is an auto immune disorder, in case of seropositive, with all the clinical manifestation, certain antibodies present like RA factor, Anti Nuclear Antibody(ANA) positive, vatari guggul is a proved medication of Amavata, formulated by Bhaisajya Ratnavali and guduchi satwa has also good result in Amavata. With the intension to prove efficacy of Vatari guggulu and Guduchi satva the study was carried out at Govt. Ayurvedic college & Hospital, Balangir taking total 100 nos of patients divided in 2 groups viz. Group-A (Sero positive RA) and Group-B (Sero negative RA). Both the trial drugs are prepared at Pharmacy attached to Dept. of Rasashastra & Bhaishajyakalpana of GAC, balangir. Trial drugs are given to both group for 30 days and effectiveness was assessed in every 15 days interval with suitable statistical tools. Result was very satisfactory in both the group with P value < 0.001. Hence it is confirmed that Vatari guggulu and Guduchi satwa are quite effective in Amavata.

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