World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

RESEARCH ARTICLE ON TO CARRY OUT PHARMACOLOGICAL EVALUATION OF KAEMPFEROL ON STRYCHNINE INDUCED CONVULSION IN LABORATORY MICE

Mr. Nilesh Sopana Kothare*, Miss. Pawar Madhuri, Miss Shital Subhash Khandagale, Dr. Hemant Kamble

ABSTRACT

The naturally occurring flavonoid kaempferol is well-known for its many pharmacological characteristics, which include neuroprotective, anti-inflammatory, and antioxidant actions. This study uses a murine model of strychnine-induced convulsions to assess kaempferol's anticonvulsant potential. Strychnine, a glycine receptor antagonist that causes seizures, was administered to laboratory mice after they had received graded dosages of kaempferol. The latency to seizure onset, length of convulsions, and survival rate were recorded and compared to control groups. Kaempferol's potential as an anticonvulsant agent was shown by the results, which showed that it greatly delayed the start of seizures, decreased the intensity of convulsions, and increased survival rates in a dose-dependent way. The study sheds light on kaempferol's potential as a treatment for convulsive disorders.

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