World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

HERB-DRUG INTERACTIONS: MECHANISM AND MITIGATION STRATEGIES

Abdul Wahid Azmatullah Khan, Pavankumar D. Chopade*, Komal Nandlal Gupta and Vedant Bipin Samant

ABSTRACT

Herb-drug interactions (HDIs) are crucial in healthcare due to the growing popularity of combining herbal supplements with traditional medications. These interactions can alter drug effectiveness or increase toxicity through pharmacokinetic and pharmacodynamic pathways. Pharmacokinetic HDIs involve changes to drug-metabolizing enzymes and transporters, affecting absorption, distribution, metabolism, and elimination. Conversely, pharmacodynamic HDIs occur when herbs interact with drug targets, impacting therapeutic outcomes. To manage HDIs, a holistic approach is vital, requiring thorough patient assessments, provider knowledge, patient education, reference to reliable sources, and regulatory support for informed decision-making.

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