World Journal of
Pharmaceutical and Life Sciences

COLORECTAL CANCER AND GENETIC SYNDROMES: CLINICAL IMPLICATIONS AND SCREENING RECOMMENDATIONS - A COMPREHENSIVE REVIEW

Sanghadeep Gajbhiye, Yash Srivastav, Manoj Kumar Katual, Anil Kumar, Shyam Narayan Mishra, Smita Pravin Godse, Monika Tirale, Tejswini Gilbile and Uriti Sri Venkatesh*

ABSTRACT

Background: Colorectal cancer (CRC) is a significant global health issue, often associated with hereditary genetic syndromes that increase individual risk. Understanding these syndromes is crucial for improving screening and management strategies. Objectives: This review aims to explore the relationship between genetic syndromes and CRC, assess current screening guidelines, and provide recommendations for clinical practice. Methods: A comprehensive literature search was conducted using databases such as PubMed, Scopus, and Web of Science, focusing on studies published in the last decade. Key terms included "colorectal cancer," "genetic syndromes," "screening guidelines," and "genetic testing." Studies were selected based on their relevance to CRC and genetic syndromes. Results: The review identifies several hereditary syndromes linked to CRC, including Lynch syndrome and familial adenomatous polyposis (FAP). Current screening guidelines often overlook high-risk populations, leading to disparities in screening practices. Barriers to genetic testing include cost, availability of counselors, and lack of awareness among patients. Future directions highlight the need for advancements in genetic research, integration of genomic data into clinical settings, and personalized screening protocols. Conclusions: Early detection and personalized management of CRC are vital for improving patient outcomes. Recommendations for clinical practice include enhancing screening protocols, increasing access to genetic counseling, educating healthcare providers, and promoting public awareness. Addressing these areas can significantly impact the prevention and management of colorectal cancer in high-risk populations.

[Full Text Article]   [Download Certificate]