World Journal of
Pharmaceutical and Life Sciences

RECENT SYNTHETIC APPROACHES TO OXADIAZOLE AND THIADIAZOLE DERIVATIVES AS BIOLOGICALLY POTENT ANTI INFLAMMATORY AGENTS

Aparna P.*, Biju C. R., Arun Lal V. B., Princy C., Ayisha Nitha P., Shalima N. K. and Babu G.

ABSTRACT

This research focused on clubbing different heterocyclic molecules having diverse biological action to produce potentially active derivatives of oxadiazole and thiadiazole. In the present study we have revealed a new synthetic approach for synthesizing novel oxadiazole and thiadiazole derivatives. Synthesis of 1, 3, 4 – Oxadiazole and Thiadiazole were carried out by the reaction between chalcone and isonicotinic acid hydrazide, followed by cyclizationwith propyl phosphonic anhydride for Oxadiazole and Hurd Mori reaction for Thiadiazole. Purity of the compounds ascertained consistency by TLC and melting point determination. The structure of newly synthesized compounds was characterized by IR, HNMR, MASS Spectral analysis. By comparing the results of all compounds, we havereached in a conclusion that 3a5 and 3b5 can be considered as potent antiinflammatory agents.

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