World Journal of
Pharmaceutical and Life Sciences

IN-VITRO EVALUATION OF CELL VIABILITY STUDIES OF THYROID CANCER USING SIMILAR MOLECULE- CABOZANTINIB

Dr. Syed Ahmed Hussain*, Nazneen, Faheem Unnisa, Arshiya Tarannum, Umaima Batool Osmani, Raheem Unnisa Shaik and Maimuna Fatima

ABSTRACT

Aim: The aim of this study is to explore and evaluate the efficacy of alternative molecules similar to lenvatinib in
the treatment of thyroid cancer, focusing on Cabozantinib oxidation B, a potential tyrosine kinase inhibitor.
Objective: To compare the anticancer effects of Cabozantinib oxidation B using various cell viability assays,
providing insights into its effectiveness in inhibiting thyroid cancer cell proliferation. Research: Five commonly
used cell viability assays, namely MTT, CellTiter-Glo Luminescent, Alamar Blue, Sulforhodamine B (SRB), and
LDH Cytotoxicity assays, were employed to analyze the cytotoxic and proliferative effects of Cabozantinib
oxidation B on cancer cells. The results were compared with those obtained using lenvatinib as the control. The
assays revealed that Cabozantinib oxidation B showed a concentration-dependent decrease in cell viability,
exhibiting significant inhibition at higher concentrations. Conclusion: Cabozantinib oxidation B demonstrated
substantial cytotoxicity and cell viability inhibition across all assays, making it a promising candidate for further
research in thyroid cancer treatment as an alternative to lenvatinib.

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