World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

IN-VIVO EVALUATION OF PREGABLIN AND 4-ISOBUTYLPYRROLIDIN-2-ONE USING ANIMAL MODELS

Dr. Syed Ahmed Hussain*, Juveria, Atika Tahreem and Ayesha Tanveer

ABSTRACT

Antiepileptic drugs on the market now can treat 50 to 80 percent of epilepsy patients. 10% to 20% of individuals taking these drugs report no improvement in seizure control. The extraction of the chemical chloroform has been significantly delayed. COMPOUND was used to lessen the quantity of LPO. The antioxidant properties of COMPOUND were demonstrated in MES-initiated shaking models by a decrease in lipid peroxidation and an increase in glutathione levels. If the free radical rummaging movement stops, repeat seizures may become more common. The treated bunches had different neuronal mobility than the control, meo-, and high-dose COMPOUND bunches. As compared to the control, the compound significantly boosted GABA levels, as well as DA, NA, and 5-HT levels.

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