World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

DEVELOPMENT AND CHARACTERIZATION OF CISPLATIN SOLID LIPID NANOPARTICLES

Siddiqua Habeeb*, Md. Hamza Habeeb, Bathula Bharathi

ABSTRACT

The aim of this study was to investigate the effectiveness of a strategy based on the development of solid lipid Nanoparticles as an innovative formulation of Cisplatin with improved therapeutic efficacy. Cisplatin SLNs were prepared by Solvent evaporation method. The solubility of drug in different solid lipids was measured. FTIR studies indicated no interaction between drug and lipid. SLN were characterized for particle size, zeta potential, entrapment efficiency and surface morphology. In vitro drug release studies were performed in phosphate buffer of pH 7.4 using dialysis bag diffusion technique. The F5 formulation had shown maximum entrapment up to 88.90 % and sustained drug release for 8 h. The scanning electron microscopy and zeta potential study showed formation of good SLN dispersion. In vitro release profiles were biphasic in nature and followed Higuchi model of release kinetics. The stability study showed successful formation of stable SLNs.

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