World Journal of
Pharmaceutical and Life Sciences

HAEMATOLOGICAL EFFECTS OF THE HYDRO-METHANOLIC SEED EXTRACT OF THE AZANZA GARCKEANA ON WISTAR RATS

M. A. Egbejimi*, S. O. Ojeka and D. V. Dapper

ABSTRACT

The hydromethanolic extract of the seed of Azanza-garckeana (Az-garckeana) fruit was evaluated for its effects on some basic haematological parameters. 25 male were divided into 5 groups of 5 rats each: Group 1 received 1ml of distilled water and served as negative control; Groups 2, 3 and 4 received respectively 500, 1500 and 3000mg/kg bw of the extract; Group received 0.2ml/kg bw of Bioferon and served as positive control. After treatments and analysis of blood samples, there was significant (p<0.05) changes in haematological parameters: Hb, PCV, mean corpuscular volume, mean corpuscular haemoglobin and neutrophil amongst the various rat groups involved in the study (p<0.05); with group 3 rats administered the medium dose of the extract having consistently and significantly lower values of these indices compared to both negative control (Group 1) and positive control (Group 5) rats (p<0.05). In conclusion, the results indicated a general reduction in the values of some red and white blood cell indices.

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