World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

DESIGN, PREPARE AND IN VITRO EVALUATION OF NANOEMULSION LOADED DEXAMETHASONE

V. Harini*, K. Prathiba, K. Jyothi and A. Yasodha

ABSTRACT

The objective of the present study was to develop and characterize an optimal stable nanoemulsion formulation of Dexamethasone with an aim to increase its bioavailability. The components for the formulation of nanoemulsion were polymers. Optimized formulation was selected for in vitro study on the basis of higher drug release, optimum globule size, minimum polydispersity value, lower viscosity, and overall lower surfactant concentration and co-surfactant. The diffusion of drug from nanoemulsion was compared with marketed formulation and we obtained better result from it. Thus nanoemulsion could be used effectively to improve the bioavailability of poorly water soluble drugs to improve their bioavailability. The nanoemulsion were optimized optical transparency, viscosity measurement, phase separation determination of pH, measurement of globule size, zeta potential, drug content, in vitro diffusion study, stability study.

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