World Journal of
Pharmaceutical and Life Sciences

A COMPREHENSIVE REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM, ITS CURRENT CHALLENGES AND FUTURE PROSPECTIVE

Gurpreet Kaur*, Ashita Pawaiya, Damandeep Kaur, Anuradha Kumari and Preetinder Kaur

ABSTRACT

Drug administration can occur in the colon both locally and systemically. Colonic drug delivery has become more and more important, not only for the delivery of medications to treat localized diseases of the colon, such as Crohn's disease, ulcerative colitis, etc., but also for the systemic delivery of therapeutic peptides, proteins, anti-diabetic, anti-asthmatic, and antihypertensive medications. The drug must be protected from deterioration, release, and absorption in the upper GI tract in order to successfully target the colon. It must also be guaranteed to release rapidly or under control in the proximal colon. In contrast to more recent Colon Targeted Drug Delivery System (CTDDS) methods like pressure-controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery (ORDS-CT), which are unique in terms of achieving in vivo site specificity and manufacturing process feasibility. This review primarily compares the primary approaches for Colon Targeted Drug Delivery System (CTDDS), namely prodrugs, pH and time dependent systems, and microbial triggered systems. These methods achieved limited success and had limitations. If a medication could be given directly to the colon, treatment might be more successful. The benefits and drawbacks of the various strategies and assessments for site-specific drug administration to the colon are also covered in this article.

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