World Journal of
Pharmaceutical and Life Sciences

A REVIEW ON DRUG-INDUCED OESOPHAGEAL DISORDERS: PATHOGENESIS, INCIDENCE, PREVENTION AND MANAGEMENT

Sneha Kashinath Landge*, Shreya Uday Mahajan, Chaitali Chandrakant Kulkarni, Prajakta Deepak Suryawanshi

ABSTRACT

Drug-induced oesophageal problems are an important clinical issue since they can cause severe pain and consequences. The goal of this study is to offer a thorough examination of the etiopathogenesis, epidemiology, and treatment of these conditions. According to epidemiology, the frequency of drug-induced oesophageal injuries is rising, especially in groups that use medications often, such the elderly and people with long-term illnesses. The pathophysiology encompasses several pathways, including as systemic effects, direct damage to the mucosa, and particular pharmacological characteristics. Commonly implicated medicines include bisphosphonates, NSAIDs, and some antibiotics. Chest discomfort, odynophagia, and dysphagia are common clinical symptoms that need for extensive diagnostic techniques such radiographic imaging and endoscopy. The use of protective agents, patient education about appropriate administration practices, and cautious drug selection are the main focuses of prevention initiatives. Pharmacological therapies, lifestyle changes, and the cessation or substitution of the offending medication are all part of management. In order to improve patient outcomes and save healthcare costs, this review emphasizes the significance of increased knowledge and proactive approaches in the prevention and management of drug-induced oesophageal diseases.

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