World Journal of
Pharmaceutical and Life Sciences

REVIEW ON ETIOLOGY, PATHOPHYSIOLOGY AND MANAGEMENT OF NEONATAL SEPSIS

Syed Nabeel Ahmad*, Shaikh Sameer Shaikh Farid, Kartik G. Jadhav and Rathod Ashwin Datta

ABSTRACT

Neonatal sepsis has distinct problems in its genesis, pathophysiology, and therapy, and it continues to be a major cause of morbidity and death globally. The current understanding of the causes, processes, and therapeutic approaches for treating neonatal sepsis is summarized in this study. Maternal infections, pathogen transmission vertically, and environmental exposures are all considered etiological factors. Pathophysiologically, sepsis sets off inflammatory reactions throughout the body, which may result in septic shock and multiple organ failure. Early detection, supportive care, empirical antibiotic medication, and improvements in diagnostic technology are all part of management. Antimicrobial resistance, variations in clinical presentation, and customized strategies according on risk factors and gestational age are among the difficulties. For infants affected by this serious illness, improved outcomes depend heavily on a thorough knowledge of the condition and prompt therapies.

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