World Journal of
Pharmaceutical and Life Sciences

GALENIC FORMULATION OF AN ANTIMICROBIAL FOAMING SOLUTION BASED ON THE HYDRO-ETHANOLIC EXTRACT OF COSTUS AFER KER-GAWL HARVEST IN CAMEROON

Yid I. Yid*, Edou Andela, Clarence Ludovic, Nnanga Ngah, Dakam William, Ngo Nyobe Caroline and Etame Loe Gisèle

ABSTRACT

This study aims to develop and evaluate an antimicrobial foaming solution using the hydro-ethanolic extract of Costus afer Ker-Gawl, a medicinal plant from Cameroon. The physicochemical characteristics of the foaming solution formulated with 2%, 4%, and 6% extract concentrations, stability, the dosage of total polyphenols (95.4 ± 2.3 mg GA Eq/g extract), total flavonoids (42.7 ± 1.8 mg Q Eq/g extract), and total saponins (13.5 ± 0.5 mg S Eq extract), as well as the antibacterial and antifungal activity, were analyzed. The Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentration (MBC) for Staphylococcus aureus (100 and 200 μg/mL respectively) and Escherichia coli (120 and 250 μg/mL respectively), and the Minimum Inhibitory Concentrations (MIC) and minimum fungicidal concentration (MFC) for Candida albicans (90 and 180 μg/mL respectively) were determined. A skin tolerance test was conducted on rabbits to evaluate the safety of the foaming solution. Results show that the foaming solution with 4% extract presents an optimal balance between stability, physicochemical properties, and antimicrobial activity, with inhibition zones ranging from 16 to 21 mm. Statistical analysis confirmed the significance of these results (p < 0.05).

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