World Journal of
Pharmaceutical and Life Sciences

PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON ANDROGRAPHIS PANICULATA

Abhishek Chowdhury*, Asutosh Banerjee and Dr. Beduin Mahanti

ABSTRACT

Andrographis paniculata, commonly known as "King of Bitters," is a medicinal plant widely used in traditional medicine systems across Asia. This review paper aims to provide a comprehensive overview of the ethnobotany, phytochemistry, pharmacology, and clinical applications of A. paniculata. The plant is rich in bioactive compounds, with andrographolide being the most abundant and extensively studied constituent. A. paniculata exhibits a wide spectrum of pharmacological activities, including hepatoprotective, immunostimulatory, antipyretic, antioxidant, antidiabetic, anti-inflammatory, antibacterial, antiviral, and anticancer effects. These properties are attributed to the presence of various phytochemicals, such as diterpenoids, flavonoids, and polyphenols. The review also discusses the safety, toxicology, and potential side effects of A. paniculata, as well as the different formulations and standardization techniques employed for its preparations. Despite the extensive research on A. paniculata, further studies are needed to fully understand its mechanisms of action, pharmacokinetics, and clinical efficacy. This review highlights the potential of A. paniculata as a promising therapeutic agent and identifies areas for future research and development.

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