World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FORMULATION AND EVALUATION OF IMMEDIATE-RELEASE TABLETS OF NAPROXEN

Addanki Anusha*, Krishna Phanisri Ponnekanti, S. Rajeshwari, Madduri kavya, Vongeti Likitha, Neeraj Kulkarni, and Nunavath Pavani

ABSTRACT

Tablets prepared by wet granulation method were found to be good without any chipping, capping and sticking. The hardness of the prepared tablets was found to be in the range of 4 to 5kg/ cm2. The friability values were found to be in the range of 0.50 to 0.72%. Disintegration time was found to be in the range of 1-3min. Formulation F6 showed good results than rest of the formulations in pre and post compression studies. The average weight and drug content of the prepared tablets indicate weight and drug content uniformity within the batches prepared. Formulation F6 (98.5%) displayed maximum drug release which shows similar drug release as that of F7, F8, but F7 and F8 were failed in mechanical properties like hardness and friability.IR-spectroscopic studies indicated that there is no drug–excipients interactions. The optimized formulation follows first order kinetics.

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