World Journal of
Pharmaceutical and Life Sciences

NECROTISING MYOSITIS: A REVIEW ON CURRENT CONCEPTS IN THE MANAGEMENT

Ansu Reji*, Catherine Toms, Beevi Fathima and Neethu R.

ABSTRACT

A uncommon and serious kind of muscle infection known as necrotizing myositis is marked by fast tissue necrosis and systemic consequences. In reviewing current concepts in the management of necrotizing myositis, this abstract places special emphasis on prognostic variables, therapeutic options, and diagnostic problems. Muscle biopsies and other imaging methods are examples of diagnostic tools that are essential for early diagnosis and separation from other illnesses. In order to stop more tissue damage and systemic dissemination, prompt commencement of vigorous antibiotic medication and surgical intervention, such as debridement, remain the cornerstones of treatment. Nevertheless, there are still issues with maximizing treatment approaches, especially when there is antibiotic resistance and a delayed diagnosis. Furthermore, developments in adjuvant medicines, such immunomodulatory drugs and hyperbaric oxygen therapy, provide possible paths toward better results. Prognostic variables influence therapy choices and prognosis, such as age, comorbidities, and tissue involvement level. For the complete care of necrotizing myositis, cooperation between multidisciplinary teams made up of intensivists, surgeons, and specialists in infectious diseases is crucial. More investigation is necessary to clarify the etiology, improve diagnostic techniques, and assess new treatment options in order to improve patient outcomes and reduce morbidity related to this difficult illness.

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