World Journal of
Pharmaceutical and Life Sciences

FORMULATION DEVELOPMENT OF METFORMIN HCL AND GLIMEPIRIDE SANDWICHED OSMOTIC PUMP TABLET

Hemavathy Saravanan*, Rajagopal Kumaravelrajan and Poojavarshini Gopinathan

ABSTRACT

An attempt was to formulate the immediate release of Glimepiride for 30 mins and control release of Metformin hydrochloride over12hrs of sandwiched osmotic pump tablets by using hydroxypropyl methylcellulose of different viscosity grades (HPMC K4M, HPMC K15M, and HPMC K100M) and disintegrants. The tablets were prepared by wet granulation technique. The granules were evaluated for angle of repose, loose bulk density, tapped and bulk density. It shows satisfactory results. The tablets were subjected to thickness, weight variation, drug content, hardness, friability, and in vitro release studies. The in vitro dissolution study was carried out for 12 h using USP dissolution apparatus II (paddle) in 900mL pH 6.8 phosphate buffer as dissolution media for Metformin HCL and 0.1N Hcl buffer as dissolution media for Glimepiride [30min]. The release mechanisms were explored and explained with zero order, first order, Higuchi, Korsmeyer peppas equations. Based on drug kinetics release, optimized formulation were selected through comparison with marketed product. It is cleared that the drug release from sandwiched osmotic pump tablets prepared by HPMC K100M provides a better result in preparation of control release formulation of metformin hydrochloride.

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