World Journal of
Pharmaceutical and Life Sciences

A REVIEW OF THE COLORECTAL DRUG DELIVERY SYSTEM

Pradip Paul, Sandeep Bag, Debasish Singha, Anuradha Shyam* and Dr. Kavitha P. N.

ABSTRACT

The oral route is the most preferred for administration but it is not suitable for lower GIT disease. Because oral route administration drugs are released at the upper GIT tract(stomach, small intestine), they will not reach the lower GIT and minimize the accessibility of drugs at the lower GIT. To overcome this difficulty specific drug delivery has been properly analyzed last two years. Colonic drug delivery systems are of enhanced importance not just for the delivery of drugs but for the treatment of several colon local diseases such as Crohr’s disease, ulcerative colitis, etc., and also other substances like protein, therapeutic peptides, anti-asthmatic drugs, anti-hypertensive drugs, anti-diabetic agents can be possible. This review article discusses, in brief, the introduction of the colon, factors affecting the colonic transition, colonic diseases, and novel and emerging technologies for colon targeting.

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