World Journal of
Pharmaceutical and Life Sciences

THERAPEUTIC POTENTIAL OF NIRGUNDI IN ARTHRITIS MANAGEMENT: A COMPREHENSIVE REVIEW

Lohith Kumar S., Mahalakshmi K. S. and Dr. Kavitha P. N.*

ABSTRACT

The versatile medicinal plant Nirgundi (Vitex negundo), exceptionally rich in phytochemicals, has been used widely in traditional medicine systems for the treatment of inflammatory diseases like arthritis. With reference to arthritis, the objective of this review is to provide a comprehensive overview of Nirgundi's pharmacological characteristics, modes of action, preclinical and clinical evidence, and safety profile. Its anti-inflammatory, analgesic, and immunomodulatory properties are attributed to key ingredients which include flavonoids, terpenoids, and alkaloids, making it an effective choice for the treatment of arthritis. Preclinical research has been proved that Nirgundi extracts and formulations work to reduce the symptoms of arthritis by a number of various processes, among which immune response modulation, oxidative stress suppression, and pro-inflammatory mediator inhibition. Nirgundi-based therapies is been shown favourable outcomes in clinical trials as well as minimal side effects.

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