World Journal of
Pharmaceutical and Life Sciences

CHARACTERISTICS AND QUALITY OF LIFE OF PATIENTS WITH DIFFICULT-TO-TREAT RHEUMATOID ARTHRITIS

Sbai Ali* and Belkhou Ahlam

ABSTRACT

Introduction:
Rheumatoid arthritis (RA) is a chronic inflammatory disease that significantly impacts quality of life. Despite advancements, some patients suffer from "difficult-to-treat rheumatoid arthritis" (DTRA). This study aims to evaluate the quality of life of active RA patients and identify factors contributing to DTRA. Method: The study employs an observational approach to gather data on the quality of life and characteristics of DTRA patients. Questionnaires are administered to patients at the rheumatology department of Saint Antoine Hospital. Statistical analyses are conducted to understand symptoms, treatments, and risk factors. Results: DTRA patients exhibit moderate disease activity despite treatments. Pain, stiffness, and fatigue are common, affecting quality of life. Comorbidities and psychosocial symptoms add complexity. Medication therapies vary, but therapeutic education and non-pharmacological approaches are underutilized. Discussion: Results underscore the importance of an individualized approach to DTRA due to its clinical and demographic diversity. Persistent symptoms, comorbidities, and lack of therapeutic education necessitate holistic management. Treatment variation highlights the need for personalized options. Conclusion: This study deepens understanding of DTRA by revealing its characteristics and challenges. Quality of life is impaired by persistent symptoms and comorbidities. Targeted interventions and increased therapeutic education could enhance management of these patients.

 

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