World Journal of
Pharmaceutical and Life Sciences

CURRENT DEVELOPMENT IN THE NANOSTRUCTURED LIPID CARRIERS (NLCs)

Anchal Sharma, Amit Sharma*, Davinder Singh and Damandeep Kaur

ABSTRACT

The drug delivery system known as nanostructured lipid carriers (NLCs) is a colloidal system with a core composed of a lipid mixture comprising both liquid and solid lipids. In contrast to polymeric or metallic nanoparticles, this lipid-based nanosystem is presented as a biocompatible, non-toxic, and safe nano-drug delivery method. Because NLC is safer, more stable, and has a higher drug loading capacity than other lipid-based nanocarriers, researchers are interested in using it to create drug carriers that are both secure and efficient. Their capacity to boost drug permeability and solubility while encasing the molecule in a lipidic shell renders them the perfect vehicle for delivering drugs via challenging delivery pathways. The application of different chemicals and surface modification of NLC lead to enhanced residence time and drug targeting. Because of these characteristics, NLCs have the potential to treat a wide range of illnesses, including diabetes, cancer, infections, neurological diseases, hypertension, and pain management. This study focuses on the latest advancements being made to employ these nanocarriers to deliver medicines and genes via various pathways. Here, we also go over the basic information, composition, kinds of NLC, and frequently used processes for producing lipid-based nanocarriers.

[Full Text Article]   [Download Certificate]