World Journal of
Pharmaceutical and Life Sciences

POTASSIUM PHENOSAN AS AN ADAPTOGEN TO STRESS

Irina Zhigacheva* and Elena Mil

ABSTRACT

Stress lead to an increase in the generation of ROS by mitochondria. It is known that antioxidants reduce the generation of ROS by these organelles. One from them is an synthetic antioxidant potassium phenosan (3,5-di-tert-butyl-4-hydroxy-phenyl propionate potassium). The aim of this work was to elucidate the effects of acute hypobaric hypoxia (AHH) and injection to animals of the potassium on the fatty acid composition of the lipid fraction membranes and bioenergetical functions of rat liver mitochondria. AHH has caused changes in the fatty acid (FA) composition in lipid fraction of mitochondria and leads to dysfunction of these organelles. Injection to rats of 10-14mol/kg of potassium phenosan has prevented the changes pool of fatty acids in lipid fraction of mitochondrial membranes and helps to restore bioenergetic characteristics of mitochondria. The drug had caused the induction Bcl-2 in spleen cells of mice and it increased their survival rates under hypoxic conditions and low temperature stress. It is assumed that protective activity of the drug due to its antioxidant activity and influence of potassium phenosan on the activity of antioxidant enzymes.

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