World Journal of
Pharmaceutical and Life Sciences

USE OF SILYMARIN IN HEPATITIS TREATMENT: A COMPREHENSIVE REVIEW

Nitish Kumar, Mahalakshmi Sampagavi* and Dr. Kavitha P. N.

ABSTRACT

Hepatitis poses a substantial global health concern, necessitating effective therapeutic interventions. Silymarin, a flavonolignan complex derived from milk thistle, is renowned for its hepatoprotective properties. This review offers a thorough examination of silymarin's potential in hepatitis treatment. It scrutinizes the molecular mechanisms underlying silymarin's actions, encompassing antioxidant, anti-inflammatory, antiviral, and immunomodulatory effects. Preclinical studies, clinical trials, and meta-analyses assessing silymarin's efficacy and safety across various hepatitis forms, including viral (hepatitis B and C), alcoholic, and non-alcoholic fatty liver disease (NAFLD), are explored. Additionally, the review discusses silymarin's synergistic interactions with conventional therapies and its role in ameliorating liver fibrosis and cirrhosis. Despite promising outcomes, challenges such as formulation variability, dosing inconsistencies, and study design heterogeneity necessitate further investigation. This review underscores silymarin's potential as an adjunctive therapy in hepatitis management, emphasizing the need for refined research to optimize its clinical application.

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