World Journal of
Pharmaceutical and Life Sciences

SPONDIAS MOMBIN ETHANOLIC LEAF EXTRACT IMPROVES HEPATIC DAMAGE INDUCED BY ALUMINIUM CHLORIDE IN A RAT MODEL

Arhoghro Ejovwoke Marcellinus*, Sylvanus Beredugo, Eric Emmauel Uchenna, Onitsha E. N., Berezi E. Peter

ABSTRACT

Introduction: Aluminum chloride (AlCl3) is highly harmful to both humans and animals, and it is extensively present throughout the environment. Spondias mombin is a medicinal plant used to treat many conditions, including liver diseases. Aim: This study assessed the preventive efficacy of Spondias mombin against hepatotoxicity produced by aluminum chloride in female albino rats. Method: fifteen adult female rats were divided to three groups, with each group consisting of five rats. Group I served as the negative control and was administered distilled water and feed. Group II served as the positive control and was administered AlCl3, whereas group III was given aluminum chloride (100mg/kg body weight) and Spondias mombin (100mg/kg body weight) for a duration of 14 days. The entire treatment was administered orally and spanned a duration of fourteen days. Blood samples were obtained and examined for variables including AST, ALT, MDA, GPx, and SOD. The results showed a significant decrease in the levels of GPx and SOD compared to the control group. Specifically, GPx reduced significantly from 9.03±0.26 to 8.66±0.07 (U/mg protein) and SOD decreased from 7.78±0.28 to 5.87±0.14 (U/mg protein) after treatment with AIC13 (P<0.05). However, the administration of Spondias mombin resulted in an increase in the levels of GPx and SOD from 8.66±0.07 to 9.03±0.27 (U/mg protein) for both enzymes. The concentration of MDA exhibited a significant increase in comparison to the control group. The value increased from 385.53±0.69 to 399.49±1.47 (nmol/g) after being treated with AlCl3. However, the administration of spondias mombin resulted in a decrease in the level of MDA from 399.49±1.47 to 385.53±0.69 (nmol/g). This decrease was significant (p<0.05) compared to the control group. Additionally, there was a significant increase in the levels of GPx and SOD in the spondias mombin treated groups compared to the AlCl3 treated groups. The results also indicated a notable reduction in AST, ALT, and MDA levels following treatment with AlCl3 in comparison to the control group. Additionally, the administration of spondias mombin extract mitigated the negative effects of AlCl3 when compared to the groups treated just with AlCl3. The histomorphological tests demonstrated that aluminium chloride caused hepato-degenerative alterations, which were mitigated by Spondias mombin. Ultimately, Spondias mombin exhibits hepatoprotective properties and hence should be promoted.

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