World Journal of
Pharmaceutical and Life Sciences

ERECTILE DYSFUNCTION IN YOUNG GENERATION- ETIOLOGY TO POSSIBLE TREATMENT: A COMPREHENSIVE UPDATED REVIEW

Uriti Sri Venkatesh, Kapil Raghuwanshi, Vishal Pathak, Hurmandeep Kaur, Rajat, Neha Singh, Sudarshan Pal, Ajay Singh Amera and Anil Kumar*

ABSTRACT

A neurovascular activity involving both spinal & supraspinal channels is an erection. Nitric oxide (NO), a
substance that increases blood flow that causes penile engorgement and erection, is released by both endothelial
cells and neurons in the final common route. The penis's phosphodiesterase (PDE) type 5 enzyme breaks down
NO. The inability to consistently get and/or sustain an erection strong enough for satisfying sexual performance is
known as erectile dysfunction (ED). This problem is caused by disruptions in the neurovascular system caused by
medicines or medical illnesses. Age-related increases in the incidence of erectile dysfunction (ED) are a consistent
finding of epidemiological investigations. However, ED symptoms are growing in frequency, especially among
younger men. Medical professionals with expertise in sexual medicine, as well as those working in other
therapeutic settings, may be well-equipped to respond to this growing need. Younger men with ED are more likely
to have their condition disregarded and ignored without having the most basic medical evaluations, such a physical
examination and gathering medical history. This is because it is commonly believed that ED in younger people is a
self-limiting illness that can be controlled with patient reassurance alone and does not require clinical assessment
or treatment. Fortunately research indicates that biological, psychological, and relational factors may also play a
role in the pathophysiology of ED in younger participants. As such, all of these factors may need to be assessed
and addressed. Surprisingly, among the organic diseases that contribute to the beginning of ED, risk factors related
to metabolism and cardiovascular health (CV) are particularly important in this age range. This review study aims
to clarify the origin, pathophysiology, and management of erectile dysfunction.

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