World Journal of
Pharmaceutical and Life Sciences

NANOTECHNOLOGY AS TARGET DRUG DELIVERY SYSTEM AS B.B.B. - A REVIEW

Dr. Abhishek Soni, Prof. Dr. Rajender Guleria, Shoaib*, Sanchit Thakur, Sahil and Nikhil Thakur

ABSTRACT

Nanoparticles such as polymeric micelles or liposomes have been developed with progress in nanotechnology and
have been applied to a wide range of fields such as drug/gene delivery. This chapter focuses on applications of
these nanoparticles for targeted drug and gene delivery. More recently, nanoparticles have been used to improve
immunity, adsorption of active oxygen, adjuvant material, virus neutralization, The blood-brain barrier (BBB) is
one of the most essential protection mechanisms in the central nervous system (CNS). It selectively allows
individual molecules such as small lipid-soluble molecules to pass through the capillary endothelial membrane
while limiting the passage of pathogens or toxins. However, this protection mechanism is also a major obstacle
during disease state since it dramatically hinders the drug delivery. In recent years, various tactics have been
applied to assist drugs to cross the BBB including osmotic disruption of the BBB and chemical modification of
prodrugs. Additionally, nanoparticles (NPs)-mediated drug delivery is emerging as an effective and non-invasive
system to treat cerebral diseases. In this review, we will summarize and analyze the advances in the drug delivery
across the BBB using various NPs in the last decade.

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