World Journal of
Pharmaceutical and Life Sciences

OPTIMIZING BUCCAL DRUG DELIVERY SYSTEMS: A MINI REVIEW OF QUALITY BY DESIGN (QbD) APPROACHES AND APPLICATIONS

Shubham Singh*, Dr. Anand Chaurasia, Dr. Dharmendra Singh Rajput, Dr. Naveen Gupta

ABSTRACT

Buccal drug delivery system has become a viable option for the effective and patient-centered administration of a
wide range of pharmacological substances. This thorough analysis examines how Quality by Design (QbD)
concepts might be used to the design and development of buccal drug delivery systems, emphasizing the major
techniques and uses that have transformed this area. The article starts out by outlining the vital role buccal drug
delivery systems play in enhancing patient adherence and treatment results, considering the special possibilities
and problems connected to this mode of drug administration. It then dives into QbD's tenets, highlighting its
methodical and comprehensive approach to the creation of pharmaceutical products. The study provides an
organized framework for the application of QbD in the development, formulation, and assessment of buccal drug
delivery systems by synthesizing the abundance of research in this field. It includes risk assessment, design space
creation, and the methodical identification of critical quality attributes (CQAs). This allows for a thorough
comprehension of the relationships between formulation factors and product performance. Furthermore, a number
of case studies and examples highlight how QbD may be used practically to optimize buccal drug delivery systems,
demonstrating how this strategy improves product quality, guarantees regulatory compliance, and speeds up the
development process. These case studies highlight the applicability of QbD concepts across a broad spectrum of
therapeutic classes, such as small compounds, peptides, and biologics. Overall, this study provides a thorough
overview of QbD's techniques, tools, and practical applications, highlighting its relevance in the development of
buccal drug delivery systems. Researchers and pharmaceutical scientists may advance patient-centric healthcare
and enhance medication delivery in a variety of therapeutic areas by implementing QbD to create novel and
efficient buccal drug delivery systems.

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