World Journal of
Pharmaceutical and Life Sciences

FOCUS ON RECEPTOR-BINDING DOMAIN OF CORONAVIRUS SPIKE GLYCOPROTEIN AS A POTENTIAL SOURCE OF NEUTRALIZING ANTIBODIES: POSSIBLE IMPLICATIONS FOR DESIGNING OF SUBUNIT VACCINE AGAINST VIRAL INFECTION

Dr. Sauradipta Banerjee*

ABSTRACT

Human coronaviruses (CoV) are enveloped positive-stranded RNA viruses belonging to the order Nidovirales, and
are mostly responsible for upper respiratory and digestive tract infections. The CoV spike glycoprotein (S) is a
structural protein that is involved in the entry of virus in the host cells. The S protein contains a conserved
Receptor Binding Domain (RBD), which recognises and interacts with the angiotensin-converting enzyme 2
(ACE2) receptors in host cells for entry. In this article, the significance of the specific domain of the surface
protein and implications to explore the same for clinical purposes in connection to treatment of viral infection has
been elucidated.

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