World Journal of
Pharmaceutical and Life Sciences

COMPARATIVE PAIN THRESHOLD INCREMENT IN EXPERIMENTAL MICE MODEL BY 2, 6-DIBENZODIOXYLMETHYLIDENECYCLOHEXAN-1-ONE (A5) AND TRAMADOL

Erigbali P. P.*, Kiridi E. G., Pughikumo D. T., Joffa P. P. K., Mainane T. and Edo P.

ABSTRACT

The study aimed to investigate the analgesic effects of two compounds designated as A5 and A6, (synthesized from
dibenzylidene) in mice model of Pain induction; as a series in research into effective and less adversely portentous
treatment options for pain management. In this controlled experimental study, mice groups were subjected to two
models of pain-inducing stimuli (hot plate, water bath) and then administered either of A5 or A6, as well as
Tramadol, a widely used analgesic drug - serving as a reference standard control; while distilled water was
administered as normal control. The study evaluated the timed relieving potential by compounds, deducing from
the latency to pain exhibited by mice in the experiment models. Results indicated that for doses of A5; at 30
minutes point (1000 mg/kg), at 60 mins point (1000 mg/kg, 1500 mg/kg), and at 90 mins point (low, mid, high) all
increased pain threshold significantly (p<0.0001, p<0.002) than normal control. Tramadol also significantly
(p<0.0001) attenuated pain responses in the mice models than control. However, there were notable differences in
their analgesic profiles. A5 demonstrated a rapid onset of action and prolonged duration of pain relief, while
Tramadol exhibited a slower onset but prolonged duration of effect. But A6 did not show any analgesic potential.
In conclusion, A5 may be beneficial as potent analgesic, although further investigation to fully elucidate the
mechanisms of action and safety profiles is recommended.

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