World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SYNTHESIS OF FLAVANOID -DERIVED ANTIMICROBIAL MANNICH BASES

Abdel Karim M,* Khalid, M.Salman and Minas A.

ABSTRACT

One flavonoid(1) was synthesized via a general synthesis protocol. Three flavonoid-derived Mannich bases(2-4) were synthesized via the Mannich reaction of 2-hydroxyacetophenone with vanillin. The structures of the target molecules were elucidated by a combination of spectral tools (IR, UV, 1HNMR, and MS). The synthesized compounds were screened for their antimicrobial activity. In cup plate agar diffusion bioassay, compound (2,3) showed activity against all test organisms at 200, 100 and 50mg/ml. The same trend was observed for compound (1). However, compounds (2) and (3) showed significant antimicrobial activity at 100 and 200mg/ml.

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