World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANTIDIABETIC POTENTIAL AND AMELIORATION OF BLOOD SERUM PARAMETERS OF THE ROOT OF CLITORIA TERNATEA ON ALBINO WISTAR RAT

Ranjit Mohapatra and Debananda Champatisingh*

ABSTRACT

Diabetes is an endocrine dysfunction that impairs immunity and has an impact on other bodily organ systems. It is
a highly prevalent condition with potentially deadly consequences all around the world. In this study, rats with
diabetes brought on by alloxan were treated with the hydroalcoholic extract of the root of Clitoria ternatea
(HARCT). The goal was to boost the body weight and blood biochemical markers associated with diabetes. The
diabetic rats were gavaged with glibenclamide (10 mg/kg) and HARCT (200, 250, and 300 mg/kg) at different
doses for fifteen days in a row. The HARCT showed more significant (P< 0.05) reduction in blood sugar level, a
significant gain in body weight, and a correction of serum protein parameters in alloxan induced diabetic albino
wistar rats compared to control and glibenclamide (10 mg/kg). Important phytoconstituents such as alkaloids,
flavonoids, steroids, coumarins, resins, and carbohydrates are found in the roots of Clitoria ternatea L. (Fabaceae).
These results provide evidence for the first time that Clitoria ternatea root may have anti-diabetic and insulinmimetic
properties.

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