World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

UNRAVELING PRECISION MEDICINE: A PHARMACOGENOMIC PERSPECTIVE OF ANTI-TUBERCULAR THERAPY - A NARRATIVE REVIEW

P. K. Malini Prithiva Kumari*

ABSTRACT

Tuberculosis (TB) treatment has undergone an evolutionary shift with the advent of precision medicine, which
provides individualized treatment plans based on patient characteristics, including genetics. Precision medicine's
cornerstone, pharmacogenomics, clarifies the impact of genetic variations on anti-TB medication response and
informs customized treatment plans. The concepts of precision medicine in anti-TB medication are examined in
this review, with particular attention to the contribution of pharmacogenomics to treatment outcome optimization
and reduction of side effects. Important genetic variations that impact medication metabolism are covered, along
with how they may affect customized tuberculosis therapy. These variations include those in the NAT2, CYP2E1,
GSTM1, GSTT1, and ABCB1 genes. This study seeks to demonstrate precision medicine's potential to transform
tuberculosis therapy and improve patient outcomes by dissecting its intricacies.

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