World Journal of
Pharmaceutical and Life Sciences

HERBAL BASED ANTIDIABETIC DRUG DELIVERY SYSTEM OF [TRIGONELLA FOENUM-GRAECUM, NIGELLA SATIVA] AND [CASSIA AURICULATA]

Nisitha S., Geetha Balasubramani*, and Paul Pradeep J.

ABSTRACT

According to the World Health Organisation, oral antidiabetic drugs are the main treatment for type 2 diabetes
mellitus, which is the most prevalent endocrine disease. However, these drugs have adverse effects, which is why
80% of people prefer traditional medications made from therapeutic plants. Scientists, researchers, and
pharmaceutical companies worldwide are increasingly embracing plants and herbal sources as potential bioactive
compounds for novel, targeted antidiabetic drugs that may control diabetes with fewer side effects than traditional
anti-diabetic medications. This study focuses on identifying the most effective herbs in reducing blood sugar levels
in type 2 diabetes. Medicinal plants are the most abundant bio source of medications for traditional systems of
medicine, nutraceuticals, food supplements, modern medicines, pharmaceutical intermediates, and chemical
entities for synthetic drugs. Over a 30-day period, this research evaluated the efficacy of herbal tea, combining
fenugreek (Trigonella Foenum-graecum) and black cumin seed (Nigella sativa), versus aavaram flower (Cassia
auriculata) in reducing blood sugar levels among highly diabetic family members. FTIR and XRD was used to
determine the chemical composition and crystallographic structure of the herbal tea, and the antimicrobial testing
was conducted against gram (+) ve bacteria, gram (-) ve bacteria and fungi. Results indicate that the fenugreek and
black cumin seed combination is more effective in lowering blood sugar levels than the avaram flower.

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