World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SUDANESE CUCURBITA PEPO (CUCURBITACEAE) FIXED OIL

Abdel Karim M,* Balsam, O. and Inas,O.

ABSTRACT

Information on the constituents of medicinal plants used in Sudanese ethnomedicine is very scarce. Hence, this study was aimed to investigate the chemical constituents of the medicinally important Cucurbita pepo seed oil and to evaluate its antimicrobial activity. 26 components were detected by GC-MS analysis. Major constituents are: 9,12-octadecadienoic acid(47.17%),hexadecanoic acid(17.16%), 9-octadecenoic acid(16.49%) and methyl stereate(12.57%). The antimicrobial activity of the oil was evaluated via cup plate agar diffusion bioassay against six standard human pathogens(Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Escherichia coli and Pseudomonasa aeruginosa and the fungi Candida albicans and Aspergillus niger). The oil showed strong activity against Escherichia coli. However, it was inactive against other test organisms. It seems that the oil is a lead for further optimization.

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