World Journal of
Pharmaceutical and Life Sciences

THE IMPACT OF TIGERNUT, DATEFRUIT COMBINATION WITH SOYBEAN EXTRACT AND LIQUID COD LIVER OIL ON HEMATOLOGICAL INDICES IN MALE WISTAR RATS

Dr. Solomon M. Uvoh*, Dr. Kiridi Emily Gabriel E. and Odikeme Eyidenghabofa David

ABSTRACT

Objective: This study was carried out by assessing the combined effect of date fruit, soybean, with Tigernut extracts and a standard drug-liquid cod liver oil on hematological indices such as PCV, RBC, and WBC, Platelet, neutrophils, eosinophil, monocytes and lymphocytes in normal male wistar rats fed for five weeks. Methods: Group1 serve as the normal control, Group2 received 1000mg/kg Tigernut extract, Group3 received 1000mg/kg Datefruit extract, Group4 received 1000mg/kg soybean extract, Group5 received combination of tiger nut and date fruit extract, Group6 received combination of Datefruit, soybean with tiger nut extract daily. All the groups received water ad libitum in addition to normal feeds. Results: The PCV percentage mean values in group2 - group7 are: 55%, 31%, 31%, 34%, 38% and 34.5% respectively compared with the control (29%) group. The WBC mean values were all increased among the test groups with an increase percentage difference above the control. Furthermore the platelet counts was predominantly increased significantly in Group5 (733x10?) administered combined extract above other test groups and control. However we observed a decreased in group7 (213x10?) platelet counts that received the standard drug compared with control (336x10?) group. There was an increased in lymphocyte count in group6 & 7 above other groups and control. Monocyte increase was observed among group2, 4 and group5. Moreso there was an increase in neutrophils count in group3 when compared with other groups. Conclusion: This study have shown a strong positive correlation between HB versus RBC and PCV with a significant p-values. White blood cells versus platelet and RBC were also positively correlated while neutrophils correlated positively with lymphocyte, eosinophil and monocytes. Hence this study reveal the Physiological capabilities of these extracts to stimulate the hematopoietic stem cell series within the bone marrows in boosting the immune defense system and increasing oxygen supply to tissues demand including vital organs in the body.

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