World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

PHARMACODYNAMIC INTERRACTIONS OF PIOGLITAZONE WITH ATORVASTATIN AND FENOFIBRATE IN RATS

Kondal Reddy J.,* Srikanth Reddy, Shravani T., Aparna Nukala, Ramya Deepthi P.

ABSTRACT

The present study suggest that Atorvastatin and Fenofibrate decrease the hypoglycemic activity of Pioglitazone by decreasing the bioavailability of Pioglitazone and when compared to Atorvastatin, Fenofibrate in combination with Pioglitazone shows a greater decrease in the hypoglycemic activity of Pioglitazone. The results are statistically significant. Even it may be required to monitor the blood glucose levels as a precautionary measure, so as to avoid the complications of severe hypoglycemia. Our studies in normal and diabetic rats suggested that drug interaction occurs between Atorvastatin, Pioglitazone and Fenofibrate when they are used concurrently in normal and diseased conditions in rats.

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