World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANTIUROLITHIATIC ACTIVITY OF SEED EXTRACT OF CUMINUM CYMINUM

Dr. Jahanara Kudsi* and Javeriya Farooqui

ABSTRACT

Urolithiasis or kidney stone disease is a urologic ailment that has a high prevalence rate worldwide and medicinal
plants have been widely used for alternative therapy. A wide range of medicinal plants have been used
conservatively for urolithiasis due to their fewer side effects and because they contain copious phytochemicals that
show advantageous effects in urolithiasis. Cuminum cyminum traditionally used in the treatment of urolithiasis.
Hyperoxaluria and hypercalciuria are among the major risk factors in pathogenesis of urinary stone formation.
Evaluation of various medicinal plants are done mainly against calcium oxalate. In this present study, the
antiurolithiatic potential in Cuminum cyminum was investigated through invitro assay. The work was performed by
using invitro Anti-urolithiatic model for calculating percentage in comparison with standard drug cystone. The
anti- urolithiatic properties were evaluated by titrimetric and turbidity assay. The result shows that for C. cyminum
folds (55%) and for standard drug cystone (82%) for titrimetric assay. For turbidity assay. C. cyminum has
significant properties (47.9±19%). The findings of the nucleation assay indicate that phytoconstituents inhibited the
crystallization of CaOx in solution. The size and the number of calcium oxalate crystals decreased with increasing
concentration upto 400μg of the phytoconstituents. The study concludes that the seed extracts of Cuminum
cyminum have inhibitory effect on calcium oxalate for crystal nucleation. It also showed great efficacy in the
dissolution of calcium oxalate crystals. Thus, this extract may be valuable resources for treatment of urolithiasis.
Acute kidney injury (AKI) is a severe problem for healthcare professionals due to its high mortality rate. The major
causes of AKI are ischemia, hypoxia, and drug-induced nephrotoxicity. AKI is particularly related to an imbalance
between oxygen and nutrients, which is caused by impaired circulation to the nephrons and increased energy
requirement due to its oxidative stress. In vitro nephroprotective studies of Cuminum cyminum reveals promising
result. Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side
effects as nephrotoxicity. The purpose of this study is to evaluate the nephroprotective activity of ethanolic extract
of Cuminum cyminum. The nephroprotective activity was dose dependent.

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