World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF VARIOUS EXTRACTS OF LEUCUS ASPERA (WILLD.) LINN. AERIAL PARTS

Tirtha Ghosh*, Swarupa Ghosh and Debabrata Devbhuti

ABSTRACT

Various Extracts of Leucus aspera (Willd.) Linn. Aerial Parts were investigated for antibacterial and antifungal
effects. Ethanolic extract (EA), Ethyl acetate extract (Eac), Petroleum Ether extract (PE) and n-butanol extract
(NB) were prepared by successive soxhlation method and estimation of zone of inhibition and Minimum inhibitory
concentration (MIC) were carried out. Among the tested strains of micro-organisms, PE extract showed maximum
inhibition though all the extracts showed antimicrobial activity and the activity was was found to be dose dependent.
Maximum activity in PE may be attributed to the hydrophobic nature of the extract which might be responsible for
breakage of lipid bilayer of cell membrane, leading to permeability dissipation and a subsequent outflow of its cell
contents. From these results, it was suggested that PE could effectively act as antimicrobial agent.

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