World Journal of
Pharmaceutical and Life Sciences

DESIGN, SYNTHESIS, CHARACTERIZATION OF PRIMIDINE DERIVATIVE AS IN MANAGING HYPERLIPIDEMIA AND ASSOCIATED RISK

Prashant Chavan, Avinash V. Patil* Rajesh Khathuriya

ABSTRACT

Hyperlipidemia is a prevalent medical condition characterized by elevated levels of lipids, including cholesterol
and triglycerides, in the bloodstream. This condition poses a significant risk factor for cardiovascular diseases due
to the accumulation of fatty deposits in arteries. Genetic, lifestyle, and dietary factors contribute to its development.
Diagnosis involves measuring lipid levels, and management typically includes lifestyle changes and medications.
Pyrimidine derivatives, on the other hand, are essential organic compounds with a six-membered heterocyclic ring
structure containing carbon and nitrogen atoms. These derivatives play a vital role in genetics and biochemistry. In
DNA and RNA, pyrimidine bases such as cytosine, thymine, and uracil form complementary base pairs with
purines, facilitating the storage and transmission of genetic information. They are also involved in metabolic
pathways, including de novo pyrimidine biosynthesis and salvage pathways. The importance of pyrimidine
derivatives extends beyond genetics. Their structural versatility has led to their use as fundamental scaffolds in
pharmaceutical compounds. Several drugs, such as anticancer agents and antiviral medications, are derived from
the pyrimidine core structure, demonstrating its significance in medicine and drug development. It highlights the
interplay between hyperlipidemia, a condition affecting cardiovascular health, and pyrimidine derivatives, crucial
components of genetics and biochemistry. Understanding both aspects contributes to advancing medical
knowledge and therapeutic strategies, addressing critical health concerns and enabling pharmaceutical innovation.

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