World Journal of
Pharmaceutical and Life Sciences

MODIFICATION OF HARIDRADI VARTI EXTRACT INTO EYE DROPS AND EVALUATION OF ITS IN VITRO ANTIBACTERIAL ACTIVITY

Dr. Ankita Prajapati* and Dr. Surekha S. Medikeri

ABSTRACT

Anjana, one of the Kriyakalpa explained in the Ayurvedic classics is indicated in various eye conditions. Netra
varti in the form of yavaakriti (wick shaped) is utilized as Anjana by rubbing on a clean surface to make a paste
and applied over the lower eyelids. As it possesses certain inconvenience while handling, application and storage
of Anjana varti, an attempt has been made to modify and develop a new dosage form of eye drops where patient
compliance, dose fixation, easy handling and storage could be achieved. Haridradi varti is a netravarti available in
Chakradatta text which contains Haridra, Daruharidra, Haritaki, Vibhitaki, Amalaki, Lodhra, Yashtimadhu and
Raktachandana. Extraction procedures play a crucial role in obtaining the therapeutic benefits of crude drugs,
ensuring the purity and concentration of active compounds in lesser dose, and facilitating the development of
various medicinal products for effective and controlled administration. Haridradi varti is extensively indicated in
various conditions of eyes and termed as sarvanetramayapaham (effective in all eye diseases). Abhishyanda is
classified under Sarvagata Netraroga which affects eye in all ways and is said to be the cause of all the eye
diseases, which can be compared to Conjunctivitis based on its signs and symptoms. Antibiotics serves the prime
base for the treatment of bacterial infections. However, misuse and overuse of antibiotics have indeed led to the
emergence of resistant strains of bacteria. Developing new antimicrobial agents with targeted drug delivery
systems is a promising approach to address this challenge. Hence an attempt has been made to develop eye drops
from Haridradi varti extract and evaluate its in-vitro antibacterial activity. The results showed promising
antibacterial activity by assessment with zone of inhibition.

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