World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF ZIDOVUDINE TRANSDERMAL PATCHES

Manasa Swapna, R. Sridhar Babu, Syed Hafeez Ahmed*, Shaik Mohd. Khasim, Fatima Zahara, Amreen Fatima, Maimoona Fatima and S. K. Nushrath Sultana

ABSTRACT

The objective of present study was to develop matrix type transdermal therapeutic systems of Zidovudine using
various such as sodium alginate, HPMCK5M and Ethyl cellulose polymers as matrix formers. Results revealed that
prepared patches showed good physical characteristics and no drug-polymer interaction was observed. The in vitro
release study revealed that F2 formulation showed maximum release in 8 hrs. Formulation F2 was subjected for
accelerated stability studies. The F2 formulation was found to be stable as there was no drastic change in the
Physico-chemical properties of the patches, which was also confirmed by FTIR. Thus, conclusion can be made that
stable transdermal patches of Zidovudine has been developed. F2 formulation showed highest cumulative
percentage drug release of 99.32% were obtained during in vitro drug release studies after 8 hrs. The release of
Zidovudine appears to be dependent on lipophilicity of the matrix. Moderately lipophilic matrices showed best
release. The predominant release mechanism of drug through the fabricated matrices was believed to be by
diffusion mechanism. Based upon the in vitro dissolution data the F2 formulation was concluded as optimized
formulation.

[Full Text Article]   [Download Certificate]