World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

INVITRO EVALUATION OF GEMCITABINE AND ITS DERIVATIVE (GEMCITABINE-ERLOTINIB) FOR THE TREATMENT OF PANCREATIC CANCER

Dr. Syed Ahmed Hussain*, Shaik Nazma Sultana, Sara Umm E. Hani, Farahanaaz Begum and Juveria Gaffar

ABSTRACT

This research paper examines the cellular impact of Gemcitabine-Erlotinib combination therapy on viability, tubulogenesis, and protein expression levels using MTT assay, Tubulogenesis assay, Indirect Immunofluorescence assay, and Western Blot analysis. The study encompasses four treatment groups: Group 1 (normal), Group 2 (Control cell line), Group 3 (Standard GEMCITABINE), and Group 4 (Gemcitabine-Erlotinib). The results suggest that Gemcitabine-Erlotinib has a significant effect on cell viability and tubulogenesis, while also affecting protein expression levels. These findings emphasize the potential impact of this combination therapy on cellular processes and warrant further investigation.

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