World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

INVITRO EVALUATION OF GEMCITABINE AND ITS DERIVATIVE (GEMCITABINE MONOPHOSPHATE) FOR THE TREATMENT OF PANCREATIC CANCER

Shaik Nazma Sultana*, Dr. Syed Ahmed Hussain, Sara Umm E. Hani, Farahanaaz Begum and Juveria Gaffar

ABSTRACT

This research paper explores the cellular effects of Gemcitabine Monophosphate on cellular viability, tubulogenesis, and protein expression levels. The study employed various assays, including the MTT assay, Tubulogenesis assay, Indirect Immunofluorescence assay, and Western Blot analysis. The research involved four treatment groups: Group 1 (normal), Group 2 (Control cell line), Group 3 (Standard GEMCITABINE), and Group 4 (Gemcitabine Monophosphate). The results indicate that Gemcitabine Monophosphate significantly affects cellular viability, tubulogenesis, and protein expression levels when compared to standard GEMCITABINE treatment, highlighting the need for further research to understand its potential implications.

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