World Journal of
Pharmaceutical and Life Sciences

ANTIESTROGENIC EFFECT OF TUBER EXTRACT OF CYPERUS ROTUNDUS L. ON THE ENDOMETRIAL THICKNESS OF MICE (MUS MUSCULUS L.)

Hendri Busman, Yanwirasti, Jamsari, Djong Hon Tjong, Mohammad Kanedi*

ABSTRACT

Uterine receptivity for implantation of an embryo is regulated by ovarian hormone estrogen. When function of the hormone is disrupted, for example by anti-estrogenic substances, the implantation process may also be disrupted. Some types of plants, including nut grass, have been known to contain anti-estrogenic compounds. The research aimed to determine the anti-estrogenic effect of tuber extract of Cyperus rotundus on the endometrial thickness of mice (Mus musculus L). By using a completely randomized design, 18 of healthy female mice, aged 3-4 months, weighing 30-40 g were grouped into three each consisted of six mice. Group-1 is mice that are given distilled water as a control. Group-2 is mice treated with anti-estrogenic drug tamoxifen of 0.16 mg/40g body weight. Group-3 is mice given tuber extract of nut garss at a dose of 135mg/40g body weight. The treatment were given once daily for 14 days. On the day 15 all mice were sacrificed, the womb was dissected to be made histological slides of uterus. The result is either tamoxifen 0.16mg/40g body weight as well as tuber extract of nut grass 135 mg/40g body weight are significantly reduce the thickness of endometrium compared with that of control. Thus it can be concluded that the tuber extract of C. rotundus has anti-estrogenic effects on the endometrial thickness of mice.

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