World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

INVITRO EVALUATION OF MEFLOQUINE AND ITS DERIVATIVE (DEHYDRO MEFLOQUINE-D5) ACTING AS ANTI MALARIAL AGENTS

Sara Umm E. Hani*, Dr. Syed Ahmed Hussain, Farahanaaz Begum, Juveria Gaffar and Shaik Nazma Sultana

ABSTRACT

This research paper explores the impact of Dehydro Mefloquine-D5 on cellular viability and tubulogenesis using MTT assay, Tubulogenesis assay, Indirect Immunofluorescence assay, and Western Blot analysis. The study encompasses four treatment groups: Group 1 (normal), Group 2 (Control cell line), Group 3 (Standard MEFLOQUINE), and Group 4 (Dehydro Mefloquine-D5). The results suggest that Dehydro Mefloquine-D5 significantly affects cell viability, tubulogenesis, and protein expression levels when compared to control and standard MEFLOQUINE treatments. These findings underline the potential impact of Dehydro Mefloquine-D5 on cellular processes and warrant further investigation.

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