World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

INVITRO EVALUATION OF GEMCITABINE AND ITS DERIVATIVE (GEMCITABINE HYDROCHLORIDE) FOR THE TREATMENT OF PANCREATIC CANCER

Dr. Syed Ahmed Hussain*, Shaik Nazma Sultana, Sara Umm E. Hani, Farahanaaz Begum and Juveria Gaffar

ABSTRACT

This research paper investigates the impact of Gemcitabine Hydrochloride on cellular viability and tubulogenesis using MTT assay, Tubulogenesis assay, Indirect Immunofluorescence assay, and Western Blot analysis. The study consists of four treatment groups: Group 1 (normal), Group 2 (Control cell line), Group 3 (Standard GEMCITABINE), and Group 4 (Gemcitabine Hydrochloride). The results suggest that Gemcitabine Hydrochloride significantly affects cell viability, tubulogenesis, and protein expression levels when compared to control and standard GEMCITABINE treatments. These findings highlight the potential impact of Gemcitabine Hydrochloride on cellular processes and warrant further investigation.

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