World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

INVITRO EVALUATION OF MEFLOQUINE AND ITS DERIVATIVE (MEFLOQUINE METHANESULFONATE) ACTING AS ANTI MALARIAL AGENTS

Sara Umm E. Hani*, Dr. Syed Ahmed Hussain, Farahanaaz Begum, Juveria Gaffar and Shaik Nazma Sultana

ABSTRACT

This research paper investigates the impact of Mefloquine Methanesulfate on cellular viability and tubulogenesis using MTT assay, Tubulogenesis assay, Indirect Immunofluorescence assay, and Western Blot analysis. The study comprises four treatment groups: Group 1 (normal), Group 2 (Control cell line), Group 3 (Standard MEFLOQUINE), and Group 4 (Mefloquine Methanesulfonate). The results suggest that Mefloquine Methanesulfonate significantly affects cell viability, tubulogenesis, and protein expression levels when compared to control and standard MEFLOQUINE treatments. These findings highlight the potential impact of Mefloquine Methanesulfonate on cellular processes and warrant further investigation.

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