World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

INVITRO EVALUATION OF MEFLOQUINE AND ITS DERIVATIVE (MEFLOQUINE HYDROCHLORIDE) ACTING AS ANTI MALARIAL AGENTS

Dr. Syed Ahmed Hussain*, Sara Umm E. Hani, Farahanaaz Begum, Juveria Gaffar and Shaik Nazma Sultana

ABSTRACT

This research paper explores the impact of Mefloquine Hydrochloride on cellular viability and tubulogenesis using MTT assay, Tubulogenesis assay, Indirect Immunofluorescence assay, and Western Blot analysis. The study includes four experimental groups: Group 1 (normal), Group 2 (Control cell line), Group 3 (Standard Mefloquine), and Group 4 (Mefloquine Hydrochloride). The results suggest that Mefloquine Hydrochloride significantly affects cell viability and tubulogenesis when compared to control and standard Mefloquine treatments. These findings have implications for understanding the potential cytotoxic effects of Mefloquine Hydrochloride on cellular processes.

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